Piperazin-2-one → HCID 86574357, compound

HRID 930112Notes

Reaction equation

HRID 930112 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([Cl:20])[CH:15]=3)=[CH:12][C:11]([C:21](O)=[O:22])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(C2N(C3C=NC=CC=3)N=C(C([N:45]3[CH2:50][CH2:49][NH:48][C:47](=[O:51])[CH2:46]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([Cl:20])[CH:15]=3)=[CH:12][C:11]([C:21]([N:45]3[CH2:50][CH2:49][NH:48][C:47](=[O:51])[CH2:46]3)=[O:22])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 231360Piperazin-2-oneHCID 715765334-[5-(3-Chloro-5-fluoro-phenyl)-1-(3-pyridyl)pyrazole-3-carbonyl]piperazin-2-oneHCID 896099331-(3-Chloro-4-fluorophenyl)-5-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86574357HCID 86574357, compound

Procedure

100 mg (0.28 mmol) of the compound of Example 68A is reacted analogously to the synthesis of the compound of Example 4 with 30 mg (0.30 mmol) of 2-oxopiperazine. 111 mg (90% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-f2aefb1788f44a2085ec99d635899cb7
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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