HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 930245Generated: October 29, 2026
Potassium Carbonate → 6-(1H-indol-6-yl)quinolin-2-amine
https://huagongshe.com/reaction/930245
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-Indol-6-ylboronic acid | HCID 2763205 | — |
| Reactant | 6-Bromoquinolin-2-amine | HCID 11183666 | — |
| Catalyst | Palladium--triphenylphosphane (1/1) | HCID 15220664 | — |
| Solvent | Dimethoxyethane ethanol | HCID 20074477 | — |
| Product | 6-(1H-indol-6-yl)quinolin-2-amine | HCID 71138504 | 54.3% |
Reaction Steps
A mixture of 1H-indol-6-ylboronic acid (43 mg, 0.27 mmol), 6-bromoquinolin-2-amine (40 mg, 0.22 mmol), K2CO3 (3M, 100 uL), PS—PPh3-Pd (20 mg, 0.11 mmol/g), and DME/EtOH (50%, 1 mL) was heated in a microwave at 140° C. for 10 min. The resulting slurry was filtered and purified by HPLC (10-60% CH3CN/water modified with 0.1% TFA) to give 6-(1H-indol-6-yl)quinolin-2-amine (31 mg). MS (ESI, pos. ion) m/z: 260 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296698B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-5f54d73e965346508ce63198e7630bc5 |
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| Source note | uspto-grants-2016_03 |
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