4,7-Dichloropyrido[3,2-d]pyrimidine → (4S,6S)-4-(5-((7-chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	4,7-Dichloropyrido[3,2-d]pyrimidine	HCID 71428445	—
Reactant	N-(5-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-chloropicolinamide	HCID 78321763	—
Product	(4S,6S)-4-(5-((7-chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine	HCID 78320811	—

Reaction Steps

The title compound was synthesized using steps and procedures analogous to those described in Method B (step 2) above, but using (4S,6S)-4-(5-amino-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (6a) and 4,7-dichloropyrido[3,2-d]pyrimidine (intermediate 9). MS m/z=456.0 [M+H]+. Calculated for C18H14ClF4N7O: 455.8

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09296734B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-85aebccf54994e4ba22888477a9d287f
Source note	uspto-grants-2016_03