HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 930324Generated: November 3, 2026
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86732152, compound
https://huagongshe.com/reaction/930324
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 86732146 | HCID 86732146 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86732152 | HCID 86732152 | — |
Reaction Steps
In a microwave vial was dissolved N-((4S,6S)-4-(2-fluoro-5-hydroxyphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (8d, 116 mg, 0.280 mmol) in MeOH (1120 μl) and added 1,8-diazabicyclo-[5.4.0]undec-7-ene (84 μl 0.560 mmol). The reaction mixture was stirred at 75° C. overnight. Cooled to room temperature. Concentrated down and used directly in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296734B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-141948795858487f9d57db162d75d12e |
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| Source note | uspto-grants-2016_03 |
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