Hydrochloric Acid → HCID 86732161, compound

Participants

Reaction Steps

To a rt solution of tert-butyl 4-(cyclopropylethynyl)-5,6-dihydropyridine-1(2H)-carboxylate (0.344 g, 1.391 mmol) in 1,4-dioxane (4.0 mL) was added hydrogen chloride, 4.0 m solution in 1,4-dioxane (4.0 mL, 16.00 mmol) dropwise via syringe resulting in a dark brown solution. After 2 h the solvent was removed in vacuo and the residue was dissolved in DCM and washed with satd. NaHCO3. The organic solution was dried over MgSO4, filtered and concentrated to dryness to give 4-(cyclopropylethynyl)-1,2,3,6-tetrahydropyridine as a brown tar (186 mg, 91%).

Provenance & Evidence