HCID 67468966, compound → HCID 78322076, compound

HRID 930351Notes

Reaction equation

HRID 930351 reaction equation
Br[C:2]1[N:7]=[C:6]([C@:8]2([CH2:27][F:28])[CH2:13][C@@H:12]([C:14]([F:17])([F:16])[F:15])[O:11][C:10]([NH:18]C(=O)C3C=CC=CC=3)=[N:9]2)[C:5]([F:29])=[CH:4][CH:3]=1.[Cl:30][C:31]1[C:32]([C:39]([NH2:41])=[O:40])=[N:33][N:34]([CH:36]([F:38])[F:37])[CH:35]=1>>[NH2:18][C:10]1[O:11][C@H:12]([C:14]([F:15])([F:17])[F:16])[CH2:13][C@:8]([C:6]2[N:7]=[C:2]([NH:41][C:39]([C:32]3[C:31]([Cl:30])=[CH:35][N:34]([CH:36]([F:37])[F:38])[N:33]=3)=[O:40])[CH:3]=[CH:4][C:5]=2[F:29])([CH2:27][F:28])[N:9]=1

Participants

3

Reactant 2

HCID 67468966HCID 67468966, compound2×HCID 86732168HCID 86732168, compound

Product 1

HCID 78322076HCID 78322076, compound

Procedure

The title compound was synthesized by procedures and steps analogous to those described in Method R, Example 134 above, except N-((4S,6S)-4-(6-bromo-3-fluoropyridin-2-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (11i) underwent the conditions described in step 10 with 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide (intermediate 32) followed by the conditions described in step 9. MS m/z=488.9 [M+H]+. Calculated for C16H12ClF7N6O2: 488.1.

Sources & evidence

ORD record
ord-2670e4cf55414b2fbd20fb0578e141d9
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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