5-Chloro-2-picolinic acid → HCID 86732216, compound

HRID 930386Notes

Reaction equation

HRID 930386 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:11][C:12]1[CH:13]=[C:14]([C@:20]2([CH3:31])[CH2:25][C@@H:24]([C:26]([F:29])([F:28])[F:27])[O:23][C:22]([NH2:30])=[N:21]2)[C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1>>[NH2:30][C:22]1[O:23][C@H:24]([C:26]([F:28])([F:29])[F:27])[CH2:25][C@:20]([C:14]2[C:15](=[O:19])[N:16]([CH3:18])[CH:17]=[C:12]([NH:11][C:8](=[O:10])[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=3)[CH:13]=2)([CH3:31])[N:21]=1

Participants

3

Reactant 2

HCID 27628725-Chloro-2-picolinic acidHCID 86732217HCID 86732217, compound

Product 1

HCID 86732216HCID 86732216, compound

Procedure

This step was performed using procedures analogous to those described in Method H Step 2 (Example 66) above, but using 5-chloro-picolinic acid and 5-amino-3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-1-methylpyridin-2(1H)-one. MS m/z=444.0 [M+H]+. Calculated for C18H17ClF3N5O3: 443.8

Sources & evidence

ORD record
ord-302d6e30a11840b489034460ee51bfc7
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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