5-Chloro-2-methoxypyrido[3,4-b]pyrazine → (4S,6S)-4-(2,3-difluoro-5-((2-methoxypyrido[3,4-b]pyrazin-5-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Participants

Reaction Steps

The titled compound was synthesized by procedure and steps analogous to those described in Method B, Example 8 above, but using (4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (17i, Example 163, Method Y, step 9) and 5-chloro-2-methoxypyrido[3,4-b]pyrazine (intermediate 3) in step 2. MS m/z=469.1 [M+H]+. Calculated for C20H17F5N6O2: 468.4

Provenance & Evidence