HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Chloro-3-methoxy-1,7-naphthyridine → (2,3-difluoro-5-((3-methoxy-1,7-naphthyridin-8-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Chloro-3-methoxy-1,7-naphthyridine | HCID 86715750 | — |
| Reactant | (4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 86732244 | — |
| Product | (2,3-difluoro-5-((3-methoxy-1,7-naphthyridin-8-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 86732248 | — |
Reaction Steps
The titled compound was synthesized by procedure and steps analogous to those described in Method B, Example 8 above, but using (4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (17i, example 163, Method Y, step 9) and 8-chloro-3-methoxy-1,7-naphthyridine (intermediate 31) in step 2. MS m/z=468.2 [M+H]+. Calculated for C21H18F5N5O2: 467.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296734B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4121dbad72374b2a887c639af36984d8 |
| Source note | uspto-grants-2016_03 |