HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3-methoxypyridine → (4S,6S)-4-(2,3-difluoro-5-((3-methoxypyridin-2-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3-methoxypyridine | HCID 90364 | — |
| Reactant | (4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 86732244 | — |
| Product | (4S,6S)-4-(2,3-difluoro-5-((3-methoxypyridin-2-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 86732266 | — |
Reaction Steps
The title compound was synthesized by procedures and steps analogous to those described in Method B, Example 8 above, but using 2-bromo-3-methoxypyridine and (4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine in step 2. MS m/z=417 [M+H]+. Calculated for C18H17F5N4O2: 416.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296734B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-be9bda7a9ca64f999f3766ed6f584f98 |
| Source note | uspto-grants-2016_03 |