HCID 50896795, compound → HCID 19619889, compound

HRID 930476Notes

Reaction equation

HRID 930476 reaction equation
FC(F)(F)COC1C(C(N)=O)=NC=CC=1.[Cl:16][C:17]1[C:18]([C:25]([O:27]C)=[O:26])=[N:19][N:20]([CH:22]([CH3:24])[CH3:23])[CH:21]=1>>[Cl:16][C:17]1[C:18]([C:25]([OH:27])=[O:26])=[N:19][N:20]([CH:22]([CH3:23])[CH3:24])[CH:21]=1

Participants

3

Reactant 2

HCID 50896795HCID 50896795, compoundHCID 66644029HCID 66644029, compound

Product 1

HCID 19619889HCID 19619889, compound

Procedure

Using an analogous reaction to that described for Intermediate 5, step 2 methyl 4-chloro-1-isopropyl-1H-pyrazole-3-carboxylate was converted into the title compound. MS m/z=188.9 [M+H]+. Calculated for C7H9ClN2O2: 188.035. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.41 (d, J=6.65 Hz, 6 H) 4.52 (quin, J=6.70 Hz, 1 H) 8.17 (s, 1 H) 12.89 (br. s., 1 H)

Workup

  1. customan analogous reaction to

Sources & evidence

ORD record
ord-a11fda627cca4fe28342e6c72fd14ed8
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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