Trifluoroacetic acid → 4-{[(1-(3,4-Dimethoxyphenyl)-3-{[4-({[(2-methylphenyl)amino]carbonyl}amino)phenyl]amino}-3-oxopropyl)amino]carbonyl}benzoic acid

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Reaction Steps

tert-Butyl-4-{[(1-(3,4-dimethoxyphenyl)-3-{[4-({[(2-methylphenyl)amino]carbonyl}amino) phenyl]amino}-3-oxopropyl)amino]carbonyl}benzoate (30 mg, 0.05 mmol) was dissolved in DCM (10 mL) and TFA (0.18 mL, 2.30 mmol) was added at 0° C. and the reaction mixture was stirred at r.t. for 24 h. The solvent was removed in vacuum and the product was isolated (25 mg, 91%). M.p. 166° C. ESI-MS: 598[M+H]+.

Provenance & Evidence