反应详情

A solution of N-(3,4,5-Trimethoxyphenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine, Intermediate 1 (75 mg, 0.24 mmol) in CH2Cl2 (1.5 mL) was cooled to 0° C. and treated with benzoic anhydride (56.7 mg, 0.251 mmol) and pyridine (22 microliter, 0.273 mmol). After 1 hour the reaction mixture was diluted with CH2Cl2 and washed with water. The organic phase was collected, dried and concentrated. The residue was purified by silica gel chromatography (15-40% acetone/CH2Cl2). The product containing fractions were concentrated to give the title compound (75 mg).

1. washwashed with water
2. customThe organic phase was collected
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography (15-40% acetone/CH2Cl2)
6. additionThe product containing fractions
7. concentrationwere concentrated