反应详情

A solution of N-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine, Intermediate 6 (75 mg, 0.33 mmol), 3-isocyanatopyridine (41.8 mg, 0.35 mmol) in CH2Cl2 (1.5 mL) was stirred at room temperature for 1 hour. After 1 hour the reaction mixture was diluted with CH2Cl2 and washed with sat. aqueous NaHCO3(aq). The organic phase was collected, dried and concentrated. The residue was dissolved in CH2Cl2 and washed with 3% aqueous LiCl solution and water. The organic phase was collected, dried and concentrated to give the title compound (45.9 mg).

1. washwashed with sat. aqueous NaHCO3(aq)
2. customThe organic phase was collected
3. customdried
4. concentrationconcentrated
5. dissolutionThe residue was dissolved in CH2Cl2
6. washwashed with 3% aqueous LiCl solution and water
7. customThe organic phase was collected
8. customdried
9. concentrationconcentrated