反应详情

温度

150 °C

{3-Benzylamino-4-[(1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester I-9″ (4.000 g; 8.648 mmol) is suspended in acetic acid (5.190 g; 86 mmol) in a microwave vial and heated in the microwave at 150° C. for 1 h. The reaction mixture is then concentrated under reduced pressure. The residue is added to ice water, precipitation occurs. The precipitate is filtered off and dried under vacuum. The residue is used in the next step without further purification. (Yield: 90%, 3.000 g; 7.763 mmol)

1. concentrationThe reaction mixture is then concentrated under reduced pressure
2. additionThe residue is added to ice water, precipitation
3. filtrationThe precipitate is filtered off
4. customdried under vacuum
5. customThe residue is used in the next step without further purification