HCID 117891965, compound → HCID 117891964, compound

Participants

Reaction Conditions

Reaction Steps

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid [6-chloro-4-(1-pyridin-2-yl-ethylamino)-pyridin-3-yl]-amide II-21″ (900 mg; 2.26 mmol) is dissolved in acetic acid (10 ml) and stirred at 150° C. for 1 h in a microwave reactor. The volatiles are removed in vacuo and the residue purified by silica gel chromatography using a DCM/Methanol gradient. The product containing fractions are combined and concentrated under reduced pressure. The product is then lyophilized to afford the desired compound.

Provenance & Evidence