HCID 117889663, compound → HCID 117894042, compound

Participants

Reaction Steps

In a hydrogenation apparatus is placed 6-[1-benzyl-2-(1-methyl-5-nitro-6-oxo-1,6-dihydro-pyridin-3-yl)-1H-benzoimidazol-5-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one F-1 (97 mg; 0.21 mmol) dissolved in 50 ml THF. A scoop of Raney-Nickel is added and the reactor filled up with H2 to 5 bar. The reaction mixture is stirred at room temperature for 1 hour. The Raney-Nickel is filtered off and the filtrate concentrated under reduced pressure. The residue is purified by using reversed phase chromatography (Method: prep. HPLC1).

Provenance & Evidence