Formic Acid → HCID 117889587, compound

Participants

Reaction Conditions

Reaction Steps

Acetic anhydride (0.050 ml; 0.518 mmol) is added to formic acid (1.000 ml; 25.974 mmol), the mixture is stirred at 50° C. for 1 h. The reaction is then cooled to RT and 3-amino-5-(1-benzyl-1H-benzoimidazol-2-yl)-1-methyl-1H-pyridin-2-one V-2 (97.000 mg; 0.294 mmol) is added in one portion. The reaction is stirred at RT for 16 h. The reaction mixture is concentrated under reduced pressure. The residue is dissolved in water/dcm (20 ml) and extracted 3 times with DCM (10 ml). The combined organic layers are dried with Na2SO4, filtered and concentrated under reduced pressure. The residue is used in the next step without further purification (yield: 88%; 93 mg; 0.259 mmol).

Provenance & Evidence