Benzylamine → HCID 117892046, compound

Participants

Reaction Steps

To a solution of 2,4-dichloro-5-nitro-pyridine E-2.1″ (5.000 g; 25.908 mmol) in NMP are added DIPEA (8.372 ml, 51.817 mmol) and benzylamine (3.054 ml, 28.499 mmol). The mixture is stirred for 1 h at RT. 1-Methylpiperazine (3.172 ml; 28.499 mmol) is then added and the mixture is stirred at 50° C. overnight. The residue is loaded onto isolute, split into 5 portions and purified using the basic preparatory reversed phase chromatography (method: prep. HPLC1). Product containing fractions are combined and freeze-dried (yield: 66%, 5.619 g; 17.163 mmol)

Provenance & Evidence