Benzylamine → 4-[4-(Benzylamino)-3-nitrophenyl]-3-methyl-4-oxobutanoic acid

Participants

Reaction Conditions

Reaction Steps

4-(4-Chloro-3-nitro-phenyl)-3-methyl-4-oxo-butyric acid E-4.1′″ (800 mg; 2.95 mmol) is placed in 8 ml ethanol and heated up to 50° C. to get solved. Benzylamine (1.61 ml; 14.73 mmol) is added and the reaction mixture stirred for 3 hours at 100° C. The crude product is purified by using reversed phase chromatography

Provenance & Evidence