huagongshe.com
HRID930623

反应详情

EQUATION

反应方程式

HRID 930623 的结构方程式

REACTANTS

反应物

2
结构：O=c1cc(-c2ccc(Cl)cc2)cc[nH]1
HCID18987294

4-(4-Chlorophenyl)pyridin-2(1H)-one

C11H8ClNO

结构：Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CC2
HCID57950375

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

C17H21BrN2O2

PRODUCTS

生成物

1
结构：Cn1c2c(c3ccc(-n4ccc(-c5ccc(Cl)cc5)cc4=O)cc31)CN(C(=O)OC(C)(C)C)CC2
HCID57950395

未命名化合物

收率 28.8%

PROCEDURE

实验过程

The compound was prepared from tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (250 mg, 0.685 mmol) and 4-(4-chlorophenyl)pyridine-2(1H)-one (100 mg, 0.418 mmol) according to the procedure in Example 1 (step c). Purification by flash column chromatography (silica gel, hexanes/EtOAc, 100:0 to 80:20 to 50:50 to 25:75 then 0:100) provided the title compound (59 mg, 18%) as a solid, that contained an impurity: ESI MS m/z 490 [M+H]+.

WORKUP

后处理

  1. customPurification by flash column chromatography (silica gel, hexanes/EtOAc, 100:0 to 80:20 to 50:50 to 25:75