4-((5-chloropyridin-2-yl)methoxy)pyridin-2(1H)-one → tert-Butyl 7-(4-((5-chloropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-((5-chloropyridin-2-yl)methoxy)pyridin-2(1H)-one	HCID 57950347	—
Reactant	tert-butyl 7-bromo-9-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate	HCID 57950468	—
Product	tert-Butyl 7-(4-((5-chloropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate	HCID 57950415	25.5%

Reaction Steps

4((5-Chloropyridin-2-yl)methoxy)pyridin-2(1H)-one (259 mg, 1.09 mmol) and tert-butyl 7-bromo-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (400 mg, 1.1 mmol) were reacted following the procedure of Example 30 (step g) to provide the title compound (145 mg, 25%) as a yellow solid: ESI MS m/z 521 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09296743B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-5c2fdcfce3b3487ea4da558cbc9c3812
Source note	uspto-grants-2016_03