4-(Trifluoromethyl)phenylboronic acid → HCID 57950378, compound

HRID 930717Notes

Reaction equation

HRID 930717 reaction equation
FC(F)(F)S(O[C:7]1[CH:8]=[N:9][N:10]([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[C:11](=[O:13])[CH:12]=1)(=O)=O.[F:22][C:23]([F:34])([F:33])[C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1>>[O:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]1[N:10]1[C:11](=[O:13])[CH:12]=[C:7]([C:27]2[CH:28]=[CH:29][C:24]([C:23]([F:34])([F:33])[F:22])=[CH:25][CH:26]=2)[CH:8]=[N:9]1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 57950357HCID 57950357, compound

Product 1

HCID 57950378HCID 57950378, compoundYield 20.6%

Procedure

6-Oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyridazin-4-yl trifluoromethanesulfonate (2.47 g, 7.5 mmol) and 4-trifluoromethylphenylboronic acid (2.56 g, 15 mmol) were reacted according to the procedure of Example 31 (step a) to provide the title compound (500 mg, 20%) as a white solid: ESI MS m/z 325 [M+H]+.

Sources & evidence

ORD record
ord-5838d5e5085146ea963fbc7bdb8ee84c
Source dataset
uspto-grants-2016_03
Patent number
US09296743B2

Reaction notes

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