Hydrochloric Acid → HCID 68656833, compound

Participants

Reaction Steps

2 N HCl in Et2O (0.12 mL, 0.24 mmol) was added to a solution of 4-(4-methoxyphenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one (45 mg, 0.12 mmol) in CH2Cl2 (2.0 mL), and the solution was stirred at ambient temperature for 2.5 h under N2. The reaction mixture was concentrated, partially diluted with H2O and lyophilized to provide the title compound (46 mg, 95%) as a yellow powder: 1H NMR (500 MHz, DMSO-d6) δ 9.26 (br s, 2H), 7.76 (d, J=9.0 Hz, 2H), 7.70 (d, J=7.0 Hz, 1H), 7.60-7.57 (m, 2H), 7.09-7.06 (m, 3H), 6.73 (d, J=2.0 Hz, 1H), 6.68 (dd, J=7.5, 2.0 Hz, 1H), 4.37-4.35 (m, 2H), 3.83 (s, 3H), 3.70 (s, 3H), 3.54-3.53 (m, 2H), 3.10 (t, J=6.0 Hz, 2H); ESI MS m/z 386 [M+H]+.

Provenance & Evidence