4-Fluorobenzyl bromide → 8-((3,4-difluorobenzyl)oxy)-1-(4-fluorobenzyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930807Notes

Reaction equation

HRID 930807 reaction equation
Cl[C:2]1[CH:11]=[C:6]2[NH:7][CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:12])[N:3]=1.Br[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1.[F:22][C:23]1[CH:24]=[C:25]([CH2:30][OH:31])[CH:26]=[CH:27][C:28]=1[F:29]>>[F:22][C:23]1[CH:24]=[C:25]([CH:26]=[CH:27][C:28]=1[F:29])[CH2:30][O:31][C:2]1[CH:11]=[C:6]2[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:12])[N:3]=1

Participants

4

Reactant 3

HCID 680214-Fluorobenzyl bromideHCID 5228333,4-Difluorobenzyl alcoholHCID 1357418828-Chloro-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 771070348-((3,4-difluorobenzyl)oxy)-1-(4-fluorobenzyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one, 1-(bromomethyl)-4-fluorobenzene and (3,4-difluorophenyl)methanol.

Sources & evidence

ORD record
ord-331841cd5c954d2396d1a468bb61367b
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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