4-Methoxybenzyl bromide → HCID 77107035, compound

HRID 930808Notes

Reaction equation

HRID 930808 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.BrC[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1.[F:24][C:25]1[CH:26]=[C:27]([CH2:32][OH:33])[CH:28]=[CH:29][C:30]=1[F:31]>>[F:24][C:25]1[CH:26]=[C:27]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:32][O:33][C:2]1[CH:12]=[C:6]2[N:7]([CH2:11][C:16]3[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1

Participants

4

Reactant 3

HCID 1650214-Methoxybenzyl bromideHCID 5228333,4-Difluorobenzyl alcoholHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 77107035HCID 77107035, compound

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one, 1-(bromomethyl)-4-methoxybenzene and (3,4-difluorophenyl)methanol.

Sources & evidence

ORD record
ord-1fdd272844c94e3bbe6ab214e9f287b8
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

Loading…