3,4-Difluorobenzyl alcohol → HCID 77107036, compound

HRID 930809Notes

Reaction equation

HRID 930809 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.BrC[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[C:18]([F:23])[CH:17]=1.[F:24][C:25]1[CH:26]=[C:27]([CH2:32][OH:33])[CH:28]=[CH:29][C:30]=1[F:31]>>[F:22][C:19]1[CH:20]=[C:21]([CH:16]=[CH:17][C:18]=1[F:23])[CH2:11][N:7]1[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=[C:2]([O:33][CH2:32][C:27]3[CH:28]=[CH:29][C:30]([F:31])=[C:25]([F:24])[CH:26]=3)[CH:12]=[C:6]12

Participants

4

Reactant 3

HCID 5228333,4-Difluorobenzyl alcoholHCID 5814364-(Bromomethyl)-1,2-difluorobenzeneHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 77107036HCID 77107036, compound

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one, 4-(bromomethyl)-1,2-difluorobenzene and (3,4-difluorophenyl)methanol.

Sources & evidence

ORD record
ord-a537c7ecab4c4da8b8ffa713e2b5d33b
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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