3,4-Difluorobenzyl alcohol → HCID 77107037, compound

HRID 930810Notes

Reaction equation

HRID 930810 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.BrC[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1.[F:24][C:25]1[CH:26]=[C:27]([CH2:32][OH:33])[CH:28]=[CH:29][C:30]=1[F:31]>>[F:24][C:25]1[CH:26]=[C:27]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:32][O:33][C:2]1[CH:12]=[C:6]2[N:7]([CH2:11][C:20]3[CH:21]=[CH:16][CH:17]=[C:18]([O:22][CH3:23])[CH:19]=3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1

Participants

4

Reactant 3

HCID 5228333,4-Difluorobenzyl alcoholHCID 40672073-Methoxybenzyl bromideHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 77107037HCID 77107037, compound

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one, 1-(bromomethyl)-3-methoxybenzene and (3,4-difluorophenyl)methanol.

Sources & evidence

ORD record
ord-fed4f1adefb345039b8588d45fb9e1c1
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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