o-Xylyl bromide → HCID 77107231, compound

HRID 930811Notes

Reaction equation

HRID 930811 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.Br[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1C.[F:23][C:24]1[CH:25]=[C:26]([CH2:31][OH:32])[CH:27]=[CH:28][C:29]=1[F:30]>>[F:23][C:24]1[CH:25]=[C:26]([CH:27]=[CH:28][C:29]=1[F:30])[CH2:31][O:32][C:2]1[CH:12]=[C:6]2[N:7]([CH2:11][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[CH3:15])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1

Participants

4

Reactant 3

HCID 6992o-Xylyl bromideHCID 5228333,4-Difluorobenzyl alcoholHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 77107231HCID 77107231, compound

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and 1-(bromomethyl)-2-methylbenzene and (3,4-difluorophenyl)methanol.

Sources & evidence

ORD record
ord-7b9458cf0233488ebd27c744b27ff73a
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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