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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 930813Generated: October 29, 2026

(3-Fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)methanol → 1-cyclopropyl-8-((3-fluoro-4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

https://huagongshe.com/reaction/930813

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)methanolHCID 66825527—
Reactant8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 90306570—
Product1-cyclopropyl-8-((3-fluoro-4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 77107233—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (3-fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl) methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296755B2
Source datasetuspto-grants-2016_03
ORD IDord-1c8cf273353641d2b583f6995c5468a5
Source noteuspto-grants-2016_03