(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanol → 1-cyclopropyl-8-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930814Notes

Reaction equation

HRID 930814 reaction equation
Cl[C:2]1[CH:14]=[C:6]2[N:7]([CH:11]3[CH2:13][CH2:12]3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:15])[N:3]=1.[F:16][C:17]1[CH:18]=[C:19]([CH:30]=[CH:31][C:32]=1[F:33])[O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][OH:28])=[CH:23][C:22]=1[F:29]>>[CH:11]1([N:7]2[CH2:8][CH2:9][CH2:10][N:5]3[C:4](=[O:15])[N:3]=[C:2]([O:28][CH2:27][C:24]4[CH:25]=[CH:26][C:21]([O:20][C:19]5[CH:30]=[CH:31][C:32]([F:33])=[C:17]([F:16])[CH:18]=5)=[C:22]([F:29])[CH:23]=4)[CH:14]=[C:6]23)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 43554868(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanolHCID 903065708-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Product 1

HCID 771072341-cyclopropyl-8-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (4-(3,4-difluorophenoxy)-3-fluorophenyl)methanol.

Sources & evidence

ORD record
ord-ca47596bfc2c4016a40029589a9552e1
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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