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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 930823Generated: October 31, 2026

4-Fluoropiperidine → 8-((3,4-difluorobenzyl)oxy)-1-(2-(4-fluoropiperidin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

https://huagongshe.com/reaction/930823

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluoropiperidineHCID 2759159—
ReactantHCID 90303921HCID 90303921—
Product8-((3,4-difluorobenzyl)oxy)-1-(2-(4-fluoropiperidin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 77107641—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E13 starting from 2-(8-((3,4-difluorobenzyl)oxy)-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidin-1-yl)acetic acid and 4-fluoropiperidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296755B2
Source datasetuspto-grants-2016_03
ORD IDord-b08a1e4bff96457ebac904f3b4563bc4
Source noteuspto-grants-2016_03