2-Amino-5-bromopyrimidine → HCID 90411524, compound

Participants

Reaction Steps

A solution of 2-bromo-1-(2-chloro-5-nitrophenyl)ethan-1-one (I-2) (30 g, 108 mmol, 1.00 equiv) and 5-bromopyrimidin-2-amine (15 g, 88 mmol, 0.81 equiv) in ethanol (300 ml) was stirred for 12 h at 75° C. and then concentrated under vacuum. The residue was diluted with 200 ml of water and extracted with 3×100 ml of ethyl acetate. The combined organic layers was washed with brine, dried over Na2SO4 and concentrated under vacuum to give 15 g (39%) of 6-bromo-2-(2-chloro-5-nitrophenyl)imidazo[1,2-a]pyrimidine (I-3) as a brown solid.

Provenance & Evidence