Bromide ion → HCID 86281290, compound

Participants

Reaction Steps

Compound 24 was synthesized using N-(3-(6-bromoimidazo[1,2-a]pyrimidin-2-yl)-4-chlorophenyl)pyrrolidine-1-carboxamide (I-15) as the bromide and (4-((methoxycarbonyl)amino)phenyl)boronic acid using a suzuki coupling protocol as described in the synthesis of I-11. The residue was redissolved in methanol and precipitation yielded the compound. m/z (ESI) of 24: 491.2 (M+H+), 1H NMR (600 MHz, DMSO-D6) δ 9.86 (s, 1H), 9.30 (d, J=2.6, 1H), 8.94 (d, J=2.6, 1H), 8.55 (s, 1H), 8.47 (d, J=2.8, 2H), 7.73 (m, 3H), 7.62 (d, J=8.5, 2H), 7.41 (d, J=8.8, 1H), 3.70 (s, 3H), 3.40 (t, J=6.5, 4H), 1.86 (t, J=6.4, 4H).

Provenance & Evidence