Bromide ion → HCID 86297147, compound

Participants

Reaction Steps

Compound 32 was synthesized using 2-methoxyethyl (3-(6-bromoimidazo[1,2-a]pyrimidin-2-yl)-4-chlorophenyl)carbamate (I-12) as the bromide and (4-((methoxycarbonyl)amino)phenyl)boronic acid using a suzuki coupling procedure described in I-13. Purification of the compound was done via mass-triggered reverse phase column chromatography preparative system (15% to 65% (B)). m/z (ESI) for 32: 496 (M+H+), 1H NMR (600 MHz, DMSO-D6) δ 10.01 (s, 1H), 9.86 (s, 1H), 9.30 (s, 1H), 8.95 (s, 1H), 8.55 (s, 1H), 8.47 (s, 1H), 7.72 (d, J=6.0, 2H), 7.62 (d, J=6.6, 2H), 7.50 (dt, J=5.7, 8.5, 2H), 4.24 (s, 2H), 3.70 (s, 3H), 3.59 (s, 2H), 3.30 (s, 3H).

Provenance & Evidence