Hydrochloric Acid → HCID 86297148, compound

Participants

Reaction Conditions

Reaction Steps

tert-butyl (4-(2-(2-chloro-5-(5-methylfuran-2-carboxamido)phenyl)imidazo[1,2-a]pyrimidin-6-yl)phenyl)(methyl)carbamate was treated with 4.0M HCl in dioxane (2 eq.) and was stirred overnight at 50° C. At completion, the reaction mixture was concentrated in vacuo and the residue was redissolved in methanol. Purification of the compound was done via mass-triggered reverse phase column chromatography preparative system (15% to 65% (B)), m/z (ESI) for 33: 460 (M+H+), 1H NMR (400 MHz, DMSO-D6) δ 10.32 (s, 1H), 9.19 (d, J=2.5, 1H), 8.90 (d, J=2.5, 1H), 8.69 (d, J=2.6, 1H), 8.56 (s, 1H), 7.93 (dd, J=2.7, 8.8, 1H), 7.53 (dd, J=1.7, 8.7, 3H), 7.34 (d, J=3.3, 1H), 6.68 (d, J=8.7, 2H), 6.35 (d, J=3.3, 1H), 6.00 (q, J=4.9, 1H), 2.73 (d, J=5.0, 3H), 2.40 (s, 3H).

Provenance & Evidence