Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromo-1-fluoro-4-nitrobenzene | HCID 69699 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 86704948 | HCID 86704948 | — |
Reaction Steps
2-Bromo-1-fluoro-4-nitrobenzene (2.5 g, 11.4 mmol), phenol (1.28 g, 13.6 mmol), and cesium carbonate (4.44 g, 13.6 mmol) were combined in dimethylsulfoxide (140 mL) and heated to 110° C. for 1 hour. The reaction mixture was partitioned between ethyl acetate and brine. The combined organics were washed with brine, dried (MgSO4), filtered and concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09296741B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-e654178404684dc196c3ded58bc407bb |
|---|
| Source note | uspto-grants-2016_03 |
|---|
