反应详情

温度

110 °C

A mixture of 2-bromo-1-fluoro-4-nitrobenzene (15 g, 68 mmol), 2,4-difluorophenol (7.82 ml, 82 mmol), and cesium carbonate (26.7 g, 82 mmol) in dimethylsulfoxide (75 mL) was heated to 110° C. for 1 hour. The reaction mixture was cooled to ambient temperature and water (1000 mL) and saturated aqueous sodium chloride (1000 mL) were added. The mixture was extracted with ethyl acetate (3×200 mL). The combined organics were washed with saturated aqueous sodium chloride, dried (anhydrous magnesium sulfate), filtered, and concentrated under reduced pressure to provide the title compound (22.5 g, quantitative).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. extractionThe mixture was extracted with ethyl acetate (3×200 mL)
3. washThe combined organics were washed with saturated aqueous sodium chloride
4. dry with materialdried (anhydrous magnesium sulfate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure