反应详情

温度

60 °C

To a solution of 196 g (1.15 mol) 1,7,10-trioxadispiro[2.2.4.2]dodecane (prepared according to Synthetic Communications, 2003, vol. 33, #12, p. 2135-2144) in 2 L methanol were added 2 L sodium methanolate (25% in methanol) and the mixture was stirred at 60° C. for 8 hours. The solvent was removed, ethyl acetate added and washed with brine. The organic layer was dried over sodium sulfate. After filtration and removal of the solvent 272 g (max. 100%) of the title compound were obtained that was used without further purification.

1. customThe solvent was removed
2. additionethyl acetate added
3. washwashed with brine
4. dry with materialThe organic layer was dried over sodium sulfate
5. filtrationAfter filtration and removal of the solvent 272 g (max. 100%) of the title compound
6. customwere obtained
7. customthat was used without further purification