Diisobutylaluminum hydride → HCID 90014767, compound

Participants

Reaction Steps

A mixture comprising 4.42 g (10.36 mmol) (RS)-ethyl 4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylate (prepared according to example 1) 350 mL tetrahydrofuran and 62.1 mL hydrido(diisobutyl)aluminum (1M in tetrahydrofuran) was stirred at 23° C. overnight. 40 mL saturated ammonium chloride was added carefully and stirring was continued for 0.5 hours. The precipitate was filtered off and washed with ethyl acetate. The product crystallized from the filtrate and was washed with water and a mixture of dichloromethane and methanol to give 3.13 g (79%) of the title compound.

Provenance & Evidence