Ammonia → HCID 90014477, compound

Participants

Reaction Steps

A mixture comprising 1.78 g (4.35 mmol) (RS)-6-{[7-(azidomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 19), 70 mL tetrahydrofuran and 2.54 g triphenylphosphine was stirred at 23° C. for 2 hours, 9.3 mL aqueous ammonia (25%) were added and stirring continued overnight. The solvents were removed and the residue was purified by chromatography to give 1.04 g (59%) of the title compound.

Provenance & Evidence