HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenyllactic acid, (S)- → HCID 118108316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenyllactic acid, (S)- | HCID 444718 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 90014477 | HCID 90014477 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 118108316 | HCID 118108316 | 46.3% |
Reaction Steps
A mixture comprising 50 mg (130 μmol) (RS)-6-{[7-(aminomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 20), 4 mL N,N-dimethylforamide, 17.5 mg N,N-dimethylpyridin-4-amine, 21.7 mg (2S)-2-hydroxy-3-phenylpropanoic acid and 54.5 mg N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate was stirred at 23° C. overnight. The solvent was removed and the residue purified by chromatography to give 32 mg (45%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296757B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-cec31d3a572d4b5d8920d1e771a498f4 |
| Source note | uspto-grants-2016_03 |