Dimethylformamide → HCID 118119944, compound

Participants

Reaction Steps

A mixture comprising 50 mg (130 μmol) (RS)-6-{[7-(aminomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 20), 5 mL N,N-dimethylforamide, 130 μL isopropyl carbonochloridate (1M in toluene) and 18.2 μL N,N-diethylethanamine was stirred at 23° C. overnight. Water was added, the solvents were removed and the residue purified by chromatography to give 25 mg (40%) of the title compound.

Provenance & Evidence