Hydrochloric Acid → HCID 118120001, compound

Participants

Reaction Steps

A mixture comprising 32.5 mg (56 μmol) tert-butyl {(2R)-4-hydroxy-1-oxo-1-[({(7RS)-4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl}methyl)amino]butan-2-yl}carbamate (prepared according to example 27), 1.0 mL 1,4-dioxane and 42.7 μL hydrochloric acid (4M in 1,4-dioxane) was stirred at 23° C. overnight. 1 mL N,N-diethylethanamine was added, the solvents removed and the residue purified by chromatography to give 6.3 mg (22%) of the title compound.

Provenance & Evidence