HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one → (RS)-N-Butyl-N-(cyanomethyl)-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one | HCID 90014948 | — |
| Reactant | (RS)-N-butyl-4-chloro-N-(cyanomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide | HCID 90015777 | — |
| Product | (RS)-N-Butyl-N-(cyanomethyl)-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide | HCID 90014553 | — |
Reaction Steps
100 mg (276 μmol) (RS)—N-butyl-4-chloro-N-(cyanomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide (prepared according to intermediate example 88a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 15.9 mg (10%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296757B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4cb5293a91f849a8a0fa359d4d711379 |
| Source note | uspto-grants-2016_03 |