N-Methylbutylamine → HCID 90014530, compound

HRID 930987Notes

Reaction equation

HRID 930987 reaction equation
[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([OH:17])=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:18][NH:19][CH2:20][CH2:21][CH2:22][CH3:23]>>[CH2:20]([N:19]([CH3:18])[C:15]([CH:13]1[CH2:12][CH2:11][C:10]2[C:3]3[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=3[S:8][C:9]=2[CH2:14]1)=[O:17])[CH2:21][CH2:22][CH3:23]

Participants

3

Reactant 2

HCID 8068N-MethylbutylamineHCID 179900774-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid

Product 1

HCID 90014530HCID 90014530, compound

Procedure

300 mg (1.12 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using N-methylbutan-1-amine to give after working up and purification 249 mg (66%) of the title compound.

Workup

  1. customto give
  2. custompurification 249 mg (66%) of the title compound

Sources & evidence

ORD record
ord-ad31d017e8b84e28a687aa9d657b43c8
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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