6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one → (RS)-N-Ethyl-N-(2-methoxyethyl)-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one	HCID 90014948	—
Reactant	(RS)-4-chloro-N-ethyl-N-(2-methoxyethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide	HCID 90014971	—
Product	(RS)-N-Ethyl-N-(2-methoxyethyl)-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide	HCID 90014552	—

Reaction Steps

100 mg (283 μmol) (RS)-4-chloro-N-ethyl-N-(2-methoxyethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide (prepared according to intermediate example 90a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 11.0 mg (7%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09296757B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-659d8dc623764b77a3b512c47f8f1d25
Source note	uspto-grants-2016_03