HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Methoxyethyl)ethylamine → (RS)-4-chloro-N-ethyl-N-(2-methoxyethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Methoxyethyl)ethylamine | HCID 546877 | — |
| Reactant | 4-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid | HCID 17990077 | — |
| Product | (RS)-4-chloro-N-ethyl-N-(2-methoxyethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide | HCID 90014971 | — |
Reaction Steps
300 mg (1.12 mol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using N-ethyl-2-methoxyethanamine to give after working up and purification 317 mg (80%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296757B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-82eb6dc8338b45549d41b224cc4d4333 |
| Source note | uspto-grants-2016_03 |