HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid → (RS)-1-[(4-Chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl)carbonyl]azetidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid | HCID 17990077 | — |
| Reactant | 3-Azetidinecarbonitrile | HCID 22132384 | — |
| Product | (RS)-1-[(4-Chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl)carbonyl]azetidine-3-carbonitrile | HCID 90014475 | — |
Reaction Steps
150 mg (558 μmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using azetidine-3-carbonitrile to give after working up and purification 72 mg (39%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296757B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0208405c7d12455eb57da24405d4a77b |
| Source note | uspto-grants-2016_03 |