HRID930991

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)CCN(Cc1ccccc1)C(=O)C1CCc2c(sc3ncnc(Cl)c23)C1

HCID90014642

未命名化合物

HCID90014948

未命名化合物

PRODUCTS

生成物

结构：COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N(CCN(C)C)Cc1ccccc1)C3

HCID72188646

未命名化合物

PROCEDURE

实验过程

146 mg (340 μmol) (RS)—N-benzyl-4-chloro-N-[2-(dimethylamino)ethyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide (prepared according to intermediate example 92a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 8.4 mg (4%) of the title compound.

WORKUP

后处理

customto give
custompurification 8.4 mg (4%) of the title compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-64478c8e37aa47a49762098b7ceb2274
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09296757B2
来源说明: uspto-grants-2016_03

反应 SMILES

[CH2:1]([N:8]([CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:9]([CH:11]1[CH2:16][CH2:15][C:14]2[C:17]3[C:22](Cl)=[N:21][CH:20]=[N:19][C:18]=3[S:24][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:30][C:31]1[C:40]([O:41][CH3:42])=[CH:39][C:34]2[NH:35][C:36](=[O:38])[S:37][C:33]=2[CH:32]=1>>[CH2:1]([N:8]([CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:9]([CH:11]1[CH2:16][CH2:15][C:14]2[C:17]3[C:22]([NH:30][C:31]4[C:40]([O:41][CH3:42])=[CH:39][C:34]5[NH:35][C:36](=[O:38])[S:37][C:33]=5[CH:32]=4)=[N:21][CH:20]=[N:19][C:18]=3[S:24][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1