HCID 90014642, compound → (RS)-N-Benzyl-N-[2-(dimethylamino)ethyl]-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

HRID 930991Notes

Reaction equation

HRID 930991 reaction equation
[CH2:1]([N:8]([CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:9]([CH:11]1[CH2:16][CH2:15][C:14]2[C:17]3[C:22](Cl)=[N:21][CH:20]=[N:19][C:18]=3[S:24][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:30][C:31]1[C:40]([O:41][CH3:42])=[CH:39][C:34]2[NH:35][C:36](=[O:38])[S:37][C:33]=2[CH:32]=1>>[CH2:1]([N:8]([CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[C:9]([CH:11]1[CH2:16][CH2:15][C:14]2[C:17]3[C:22]([NH:30][C:31]4[C:40]([O:41][CH3:42])=[CH:39][C:34]5[NH:35][C:36](=[O:38])[S:37][C:33]=5[CH:32]=4)=[N:21][CH:20]=[N:19][C:18]=3[S:24][C:13]=2[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 90014642HCID 90014642, compoundHCID 900149486-amino-5-methoxy-1,3-benzothiazol-2(3H)-one

Product 1

HCID 72188646(RS)-N-Benzyl-N-[2-(dimethylamino)ethyl]-4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

Procedure

146 mg (340 μmol) (RS)—N-benzyl-4-chloro-N-[2-(dimethylamino)ethyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide (prepared according to intermediate example 92a) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 8.4 mg (4%) of the title compound.

Workup

  1. customto give
  2. custompurification 8.4 mg (4%) of the title compound

Sources & evidence

ORD record
ord-64478c8e37aa47a49762098b7ceb2274
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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